Glyphosate exposure linked to potential irreversible brain damage
Scientists from Arizona State University warn that glyphosate, a popular pesticide, may result in permanent brain damage, even in doses previously considered safe.
Research carried out by scientists at Arizona State University has demonstrated that exposure to glyphosate, a widely used pesticide, may lead to irreversible brain damage. The findings published in the "Journal of Neuroinflammation" indicate that even short-term exposure to this herbicide causes significant brain inflammation, similar to that seen in Alzheimer's disease.
The studies were conducted on mice, and they suggest the brain is much more vulnerable to the adverse effects of glyphosate than previously believed.
Glyphosate and Brain Health
Glyphosate is one of the most commonly used herbicides worldwide. In Poland, 92 plant protection products containing this substance have been registered. Research suggests that glyphosate exposure can lead to neurodegenerative changes, premature death, and anxiety disorders.
Additionally, it has been proven that a metabolite of glyphosate, aminomethylphosphonic acid (AMPA), accumulates in the brain tissues of the tested animals, raising concerns about its safety for humans.
The research indicates that even after a six-month period without exposure to the herbicide, symptoms did not diminish. As noted by Prof. Ramon Velazquez, one of the study's authors, the findings provide further evidence of the brain's vulnerability to glyphosate.
Given the growing prevalence of cognitive disorders among the aging population, especially in rural regions where glyphosate is commonly applied, there is a pressing need for further investigation into the impact of this herbicide, he notes.
Glyphosate is common and harmful
Glyphosate is extensively used in agriculture, particularly in maize, soybeans, sugar beets, alfalfa, wheat, and cotton. Its use has increased since 1996 when plant varieties resistant to it were developed. Its widespread application increases the risk for farmers who are most exposed to its harmful effects. The substance can enter the body through the skin and respiratory tract.
However, glyphosate is pervasive throughout the food chain, affecting the air, soil, and surface waters. As a result, a significant portion of the US population has been exposed to it. Consuming food with glyphosate residues poses a potential health risk.
Need for further research
The U.S. Environmental Protection Agency recognises certain levels of glyphosate as safe, but an increasing number of studies, including this one, question these limits. Glyphosate and its metabolites can cross the blood-brain barrier, highlighting the need to reassess its safety. The International Agency for Research on Cancer classifies it as "possibly carcinogenic to humans."
Scientists in Arizona examined the impact of glyphosate on two types of mice: healthy ones and those genetically modified to develop Alzheimer's-like symptoms. In both cases, an increase in inflammatory markers in the brain and blood was observed.
Two doses were tested: a high dose, familiar from previous studies, and a lower dose, corresponding to the permissible human dose. Even short-term exposure to doses considered safe can lead to long-lasting changes in brain function.
The authors of the publication highlighted that even brief exposure to glyphosate can trigger lasting inflammatory processes that harm brain health. They expressed hope that their findings would inspire additional research into its potential health effects.
